There is a paucity of data on mammal species richness in the Piedmont physiographic province of the Carolinas, especially in north-central South Carolina. Over the last 12 years, I conducted field surveys, searched the literature, and queried numerous museums and agencies to locate records of mammals from the Piedmont province of South Carolina. I recorded 43 species of mammals, four of which are listed as species of state concern, from six counties in north-central South Carolina. Baseline information on mammal species occurrence is critical to future studies and issues of management and conservation.